There are approximately 90 National Mission Institutions in covenant relationship with the United Methodist Women national office. They are located in cities, small towns throughout the United States, including Puerto Rico. They provide services to all persons without regard to race, color, national origin, religion, sexual orientation and political persuasion. They are ministries with the poor, elderly, women, children, youth, families and communities.

The national office provides the institutions with access to United Methodist Women (local, district, conference), networking opportunities, technical and financial resources, and staff consultation. Approximately 50 percent of the institutions are housed in property owned by the national office.